Preuve de concept pour le profil OÉAF : consultation des cours dans le cadre des programmes de doctorat en administration (HEC, UQAM, McGill et Concordia)

Tiré de l'écran-titre (visionné le 27 juin 2017).L'actuel document présente les travaux réalisés sur un outil d’extraction et de conversion des données à partir d’une base de données institutionnelle. Ce projet se veut une preuve de concept pour le profil OÉAF

Développement MLO: Metadata for learning opportunities

Tiré de l'écran-titre (visionné le 27 juin 2017).Ce rapport d'études présente les résultats des travaux de développement d’outils d’extraction et d’exploitation des métadonnées sur les opportunités d’apprendre. Les résultats de leur utilisation témoignent du fort potentiel de la spécification MLO-AD

Modélisation pour la gestion de modèles

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal

From Negative Aspects and Black Aspects of Vietnam Education to Lessons for Social Sciences Students

In our research, we level strong criticism at the State Professor Council in Vietnam, using the case of Tran Van Tho and other members as a representative illustration of their efforts to impede or restrict the growth of the nation's scientific community. We also do not place enough importance on the publication of bogus news online by various Vietnam publications (Thanhnien.vn and Tuoitre.vn), despite the fact that it may lead to confusion, as well as problems and concern in the community. In addition, we oppose the excessive tuition fees and other expenses that have been imposed by Banking University HCM city Vietnam and other institutions in HCM city in recent years, which have caused difficulties for families, parents, students, and society as a whole. In addition, we use these problematic aspects of the education system in Vietnam as a case study to instruct students majoring in social sciences. After that, the authors apply a strategy based on the laws of Malaysia in order to solve the problem of fake news published in the newspapers tuoi tre and thanh nien in Vietnam throughout the period 2015-2022. After the case discussion that was offered earlier, the authors assess the opinions of President Ho Chi Minh on publishing activities for the purpose of better teaching pupils. This is not the least of the authors' contributions

MÔ PHỎNG ẢNH HƯỞNG CỦA MỰC NƯỚC BIỂN DÂNG ĐẾN BIẾN ĐỘNG ĐỊA HÌNH ĐÁY VÙNG VEN BỜ CỬA SÔNG MÊ KÔNG

This paper presents some study results on morphological change in the coastal region of Mekong River under the influences of sea level rise. In order to set up the models, measured data were collected, systematically and homogeneously processed to create open boundary conditions (time-serial data) for the model. Open sea boundary conditions of the model were created by NESTING method. The model (Delft3D model) was set up with 4 layers in Sigma coordinate. The results of model were validated, showing a fairly good agreement with measured data (water elevation, currents, and suspended sediment concentration) at some places in the study area. Results of some scenarios of simulation (dry and flood season) show the sea level rise due to climate change could make a reduction in the seaward sediment transport and increase its settling around estuaries. As a result, sea level rise causes an increase in the accreted rate of sandbars in southern estuary of Mekong river coastal area. The influences of sea level rise on Mekong river coastal bed topography are prevailing in the region of about 7 - 10 km seawards. Further 10 km from the coast, influences of sea level rise on coastal morphology are not significant.Bài báo trình bày các kết quả nghiên cứu dự báo biến động địa hình ở vùng ven bờ châu thổ sông Mê Kông dưới ảnh hưởng của nước biển dâng. Để thiết lập mô hình tính, các chuỗi số liệu quan trắc đã được thu thập, xử lý hệ thống và đồng bộ cho các điều kiện biên (sông, biển) của mô hình dạng chuỗi số liệu (time serial data). Các biên mở phía biển của mô hình được tạo ra bằng phương pháp lưới lồng (NESTING) từ mô hình có miền tính rộng hơn ở phía ngoài. Mô hình Delft3D với 4 lớp độ sâu theo hệ tọa độ Sigma đã được thiết lập và kiểm chứng cho thấy có sự phù hợp với số liệu đo đạc. Kết quả dự báo trong mùa cạn và mùa lũ đã cho thấy sự dâng cao mực nước biển do biến đổi khí hậu làm hạn chế sự phát tán của dòng trầm tích về phía biển và tập trung di chuyển quanh các cửa sông. Qua đó làm tăng tốc độ bồi tại các bãi bồi khu vực phía ngoài các cửa sông phía nam của vùng ven bờ châu thổ sông Mê Kông. Những ảnh hưởng do dâng cao mực nước biển đến địa hình đáy ven bờ châu thổ sông Mê Kông phổ biến diễn ra trong phạm vi khoảng 7 -       10 km từ cửa sông ra phía ngoài. Ở phía ngoài 10 km từ bờ ra, ảnh hưởng do dâng cao mực nước đến địa hình đáy hầu như không đáng kể

Purification and thrombolytic effects in vivo of recombination Nattokinase on carrageenan-induced tail thrombosis in a rat model

Nattokinase is a serine protease with fibrinolytic activity and has been proven clinical efficacy and safety for human use by the oral route. In this study, conducted purified recombinant nattokinase from Bacillus subtillis DB104 strain and thrombolytic effects of nattokinase have been observed in vivo. The result of the enzyme purification by membrane filtration method for enzyme recovery efficiency is 82.45%. Then the enzyme was purified to Q-Sepharose ion exchange chromatography with a purification factor of 1.82 and at a yield of 66.91%. Enzyme activity was 5,457 FU/mg protein. With the carrageenan-induced tail thrombosis in a rat model, results were significantly reduced by 67.3 to 83.6% at oral doses and injected nattokinase compared with the control group at 48 h. At 72 hours the rate increased to 82-89% in the oral dose and up to 91% in the injected dose nattokinase and comparable to 90% for heparin-positive hepatitis

The role of nutritional risk evaluation in predicting adverse outcomes among patients with severe COVID-19 in Vietnam

IntroductionAs sufficient nutrition helps alleviate catabolic stress and modulate the systemic inflammatory response of the body, it plays an indispensable role in the good prognosis of critically ill patients. Thus, this study aimed to investigate the malnutrition of patients with severe COVID-19 and its association with adverse treatment outcomes.MethodsWe conducted a retrospective cross-sectional study in two provincial hospitals in Hanoi from February to April 2022. Participants were patients with severe COVID-19 admitted to the Intensive Care Unit (ICU). Malnutrition risk were evaluated by Nutritional Risk Screening-2002 (NRS), Global Leadership Initiative on Malnutrition (GLIM), Prognostic Nutritional Index (PNI), and the adverse prognosis was assessed by Acute Physiology and Chronic Health Evaluation II (APACHE II). The multivariate receiver-operating characteristic (ROC) curve was applied to estimate the predictive ability of those criteria regarding worse treatment results.ResultsThe percentages of malnutrition measured by NRS, GLIM, PNI, and BMI were 62.6, 51.5, 42.9, and 16.6%, respectively. Patients with more severe malnutrition assessed by GLIM, PNI, and having above target fasting blood glucose (FBG) (≥10.0 mmol/L) were more likely to have higher APACHE scores. PNI had a better diagnostic performance than NRS and BMI (AUC = 0.84, 0.81, and 0.82, respectively). In addition, FBG revealed a good prognostic implication (AUC = 0.84).ConclusionA relatively high percentage of patients experienced moderate and severe malnutrition regardless of screening tools. Individuals at higher risk of malnutrition and high FBG were predicted to have more adverse treatment outcomes. It is recommended that nutritional screening should be conducted regularly, and personalizing nutritional care strategies is necessary to meet patients’ nutrient demands and prevent other nutrition-related complications

Assessment of Antioxidant and Antibacterial Activities of Lactobacillus farciminis HN11 as a Probiotic Candidate

Background and Objective: Lactobacillus farciminis is an obligate homofermentative bacterial species in fermented foods. Although other species such as Lactobacillus plantarum, Lactobacillus acidophilus, Lactobacillus casei and Lactobacillus rhamnosus in Lactobacillus genus have been well characterized, probiotic characteristics of Lactobacillus farciminis still need to investigate. Thus, the objective of this study was to investigate probiotic characteristics and antibacterial activity of Lactobacillus farciminis HN11 isolated from Solanum macrocarpon sauces in Hue city, Vietnam. Material and Methods: Lactobacillus farciminis HN11 was cultured in Rogosa and Sharpe media and antibacterial activity of the free-cell suspension was assessed against Escherichia coli, Vibrio parahaemolyticus K5, Vibrio parahaemolyticus KS-02, Vibrio owensii KS-05, Vibrio alginolyticus KS-08, Vibrio alginolyticus A1-1 and Staphylococcus aureus using agar well diffusion method. Various probiotic characteristics of the isolate including antibacterial and antioxidant activities, autoaggregation and coaggregation were assessed. Furthermore, hemolytic and amino-acid dercarboxylase activities were assessed for biosafety assessment. The strain abilities to resist sodium chloride and bile salts were assessed as well. Results and Conclusion: Lactobacillus farciminis HN11 exhibited significant resistance to NaCl and bile salts. The strain expressed high coaggregation abilities for Escherichia coli, significant autoaggregation abilities and antibacterial activities against Vibrio spp. and Escherichia coli. Antioxidant assessment showed that Lactobacillus farciminis HN11 contained high antioxidant activities. This strain was negative for hemolytic and amino-acid dercarboxylase activities. Moreover, ampicillin and chloramphenicol inhibited growth of Lactobacillus farciminis HN11. This study assessed characteristics of Lactobacillus farciminis HN11 and showed its great potentials as a probiotic in fermented foods, enhancing antioxidant and decreasing harmful foodborne bacteria. Although, encapsulation of the strain within acid resistance materials is suggested to better protect it against high-acid contents of the stomach. Conflict of interest: The authors declare no conflict of interest

H2_{2}O2_{2} production in Lactobacillus strains isolated from the intestinal microbiome of healthy people

Lactobacillus sp. in the digestive tract are capable of producing H2O2 to inhibit the growth of harmful bacteria and balance the gut microflora. In this study, we have isolated 115 strains of Lactobacillus spp. from stool samples of healthy people in Ha Noi. Of the 50 tested Lactobacillus strains, 9 strains were capable of producing H2O2, of which the Lac.VFE-14 strain produced highly H2O2 with a concentration of 2.183 mM, followed by Lac.VFE-08 strains (2.081 mM) and Lac.VFE-04 (2.067 mM). All three strains grew well in MRS medium supplemented with bile salts or adjusted to low pH value. With 0.3% of bile salt, the survival rates of these 3 strains were 99%, 95% and 97%, respectively. At pH 3.0, after 3 hours of cultivation, the survival rates of the three strains were 98.54%, 94.15% and 95.27%, respectively. In addition, each of the cell-free culture supernatants of these three strains that inhibit the growth of S. aureus ATCC-23235. The inhibition zone diameters of the three strains were 19.0±1.0 mm, 14.0±1.0 mm and 11.7±1.3 mm, respectively. The results of 16S rRNA gene analyses showed that Lac.VFE-14, Lac.VFE-08 and Lac.VFE-04 had high similarity scores with L. plantarum ZZU 23 (100%), L. rhamnosus JCM 1136 (99%) and L. plantarum S7 (98.65%), respectively. This study indicates that all three strains have the potential to be used as probiotics in the future. 

In vitro bioactivities of Codonopsis javanica root extract from Kon Tum province, Vietnam

Dangshen Codonopsis javanica exhibits invaluable medicinal properties in herbal remedies; however, there has currently not been much specific analysis of the phytochemicals and bioactivities of this plant. The root ethanol extract of C. javanica contains substances such as saponins, phenolic acids, terpenoids, and alkaloids. It displays an antibacterial effect against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus cereus with the IC50 values of 150, 100, 150, and 90 μg/mL, respectively. The antioxidant capacity of the root extract was also observed with an IC50 value of 46.8 ± 6.8 μg/mL. Furthermore, the extract exhibits activity on human cancer cell lines HepG2 (IC50 = 83.6 ± 2.7 μg/mL) and MCF-7 (IC50 = 95.3 ± 2.3 μg/mL). Hence, this study provides the basic data for further research on the bioactivities of natural compounds of Dangshen C. javanica for the first time